Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively
K. Raina, C. D. Forbes, R. Stronk, J. P. Rappi, K. J. Eastman, S. W. Gerritz, X. Yu, H. Li, A. Bhardwaj, M. Forgione, A. Hundt, M. P. King, Z. M. Posner, A. Denny, A. McGovern, , C. M. Crews
This paper introduces RIPTACs, a new class of heterobifunctional small molecules that selectively kill cancer cells by inducing protein-protein interactions that disrupt essential cellular functions.
bioRxiv · Jan 1, 2023 · PreprintCancer Biology