H. Li

Transglutaminase 3 is a Histone Monoaminylation Writer

The paper identifies TG3 as a new histone monoaminylation writer capable of catalyzing H3Q5 histaminylation.

Scalable Generation of Clinical-Grade Universal Human cDC1s Enables Potent Antitumor Immunotherapy

This paper develops a scalable method to generate clinical-grade cDC1s from umbilical cord blood, showing improved antitumor efficacy in mouse models and recapitulating DC differentiation.

Defence recognition of a stripe rust fungal effector is uncoupled from disease outcomes in wheat

The paper identifies an AvrPstB48 effector from stripe rust fungus that triggers defence responses in wheat but does not directly correlate with disease outcomes.

Histone marks enable formation of immiscible phase-separated chromatin compartments

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Dynamic B0 field shimming for improving pseudo-continuous arterial spin labeling at 7 Tesla

This paper develops a dynamic B0 field shimming method for 7T PCASL to improve labeling efficiency and perfusion signal by correcting off-resonance in brain-feeding arteries.

Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

This study evaluates cipargamin's efficacy against Babesia species and identifies resistance mechanisms, showing its effectiveness as an anti-babesial drug but limitations due to resistance, with combination therapy with tafenoquine offering potential.

Preclinical evaluation of pharmacological inhibition of SIRT1 on the growth of tumoral and metastatic granulosa cells

This study evaluates SIRT1 inhibition's effect on granulosa cell tumor growth and metastasis using in vitro and in vivo models, finding reduced tumor progression with EX-527 treatment.

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

CREEPING STEM1 Regulates Directional Auxin Transport for Lodging Resistance in Soybean

This study identifies the CS1 gene in soybean, which regulates directional auxin transport and enhances lodging resistance, improving yield under high planting density.

Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics

This study shows magnesium enhances bacterial antibiotic resistance by altering phospholipid metabolism, specifically increasing phosphatidylglycerol and decreasing phosphatidylethanolamine.

Lectins and polysaccharide EPS I have flow-responsive roles in the attachment and biofilm mechanics of plant pathogenic Ralstonia

This study shows that Ralstonia pseudosolanacearum lectins and EPS I have dual roles in biofilm attachment and mechanics depending on environmental flow conditions.

Chemically induced cell plasticity enables the generation of high-fidelity embryo model

This paper develops a chemical-only method to generate high-fidelity embryo models by inducing cell plasticity in stem cells, resulting in embryo-like structures that recapitulate early developmental stages.

RSG-YOLO: Detection of rice seed germination rate based on enhanced YOLOv8 and multi-scale attention feature fusion

This paper introduces RSG-YOLO, an enhanced YOLOv8 model for rice seed germination rate detection, achieving a 4% improvement in mAP50 over YOLOv8.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Flight-Scope: microscopy with microfluidics in microgravity

Flight-Scope enables live-cell imaging of dynamic processes in microgravity using microfluidics during parabolic flights, demonstrated with yeast glucose uptake.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Landscape and meteorological variables associated with Aedes aegypti and Aedes albopictus mosquito infestation in two southeastern USA coastal cities

The paper examines landscape and meteorological factors influencing Aedes mosquito infestation in Miami and Charleston, finding significant associations between weather variables and mosquito abundance.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

PEX14 functions as a molecular link between optineurin and pexophagy in human cells

This study identifies PEX14 as a molecular link between optineurin and pexophagy, elucidating its role in recruiting autophagic machinery for peroxisome degradation.

Molecular Mechanism of Huanglian Jiedu Decoction in Treatment of Alzheimer's Disease based on Network Pharmacology

This study uses network pharmacology to identify the molecular mechanism of Huanglian Jiedu Decoction in treating Alzheimer's disease, revealing its anti-inflammatory effects through multiple targets and pathways.

SlSAURs, targeted by SlSTOP1, inhibit SlPP2C.Ds to modulate H+-ATPase and tomato root elongation under aluminum stress

This study identifies SlSAURs as regulators of root elongation under aluminum stress by interacting with SlPP2C.Ds to modulate H+-ATPase activity.

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

Enhancing Whole Slide Image Classification with Discriminative and Contrastive Learning

This study improves whole slide image classification by using discriminative and contrastive learning to create WSI-level positive and negative samples, enhancing classification performance and feature robustness.

Flat-field superresolution structured illumination microscopy with joint temporal-spatial light modulation

This paper introduces a flat-field structured illumination microscopy method to improve field uniformity and enable large-scale imaging of whole cells and pathological samples.

Rhizobial effector NopM ubiquitinates Nod factor receptor NFR5 and promotes rhizobial infection in Lotus japonicus

This study identifies NopM as a rhizobial effector that ubiquitinates NFR5, enhancing infection of Lotus japonicus by modulating Nod factor signaling.

A genetic and microscopy toolkit for live imaging of whole-body regeneration in Macrostomum lignano

This paper develops a toolkit for live imaging of whole-body regeneration in flatworms, revealing neuron regenerative limitations and independent nerve cord reconnection.