X. Yu

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Systematic Multi-Omics Investigation of Androgen Receptor Driven Gene Expression and Epigenetics changes in Prostate Cancer

This study investigates AR-driven gene expression and epigenetic changes in prostate cancer using multi-omics data from LNCaP cells, identifying gene expression shifts and AR binding patterns under androgen deprivation therapy.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Condenzymes: Biomolecular condensates with inherent catalytic activities

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages

This study develops a nanobody-enzyme fusion protein targeting PD-L1 and sialic acid, showing anti-tumor effects by modulating tumor-associated macrophages.

Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1alpha-mediated glycolysis

This study identifies that impaired NK cell migration in HIV-infected individuals is due to TIGIT inhibiting HIF-1-mediated glycolysis through PI3K/AKT/mTORC1 or ERK pathways.

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.

An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut

This paper develops an ingestible, battery-free robotic interface for chronic gut electrostimulation, showing it can modulate ghrelin levels and has potential for treating gastrointestinal conditions.

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells

This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.

Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity

This paper develops a first-in-class RIPK1 degrader, LD4172, which enhances antitumor immunity by promoting immunogenic cell death and sensitizing tumors to anti-PD1 therapy.

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

Engineering customized viral receptors for various coronaviruses

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling

This study uses predictive modeling to analyze global patterns of African Horse Sickness, identifying high-risk areas and highlighting the impact of climate on disease transmission.

TomoNet: A streamlined cryoET software pipeline with automatic particle picking on flexible lattices

TomoNet is a cryoET software pipeline with automatic particle picking and subtomogram averaging, achieving high-resolution 3D structures from flexible lattices.

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.

Screening of associated bacteria of Alexandrium catenella on affecting PSTs production and influence mechanism

The paper screens associated bacteria of Alexandrium catenella to identify those affecting PSTs production and investigates their influence on physiological and molecular processes.

Optimisation of the extraction process of naringin dihydrochalcone and its effect on reducing blood lipid levels in vitro

This study optimizes naringin extraction and evaluates naringin dihydrochalcone's lipid-lowering effect in HepG2 cells.

Evolution of glucuronoxylan side chain variability in vascular plants and the counter-adaptation of pathogenic cell-wall-degrading hydrolases

The paper identifies the genetic basis of xylan side chain variability in plants and shows how pathogens adapt to degrade these structures, revealing evolutionary adaptations in both biosynthesis and degradation.

Unveiling the regulatory role of GRP7 in ABA signal-mediated mRNA translation efficiency regulation

This study identifies GRP7 as a key regulator of ABA-mediated translation efficiency in Arabidopsis by modulating pre-rRNA processing and ribosome distribution.

PCTA, A PAN-CANCER CELL LINE TRANSCRIPTOME ATLAS

PCTA provides a curated pan-cancer cell line transcriptome atlas with user-friendly tools for gene expression analysis across diverse cancer types.

A Murine Model of Post-acute Neurological Sequelae Following SARS-CoV-2 Variant Infection

This study uses a murine model to investigate persistent neurological symptoms after SARS-CoV-2 Delta variant infection, finding long-term immune activation and behavioral abnormalities.

Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory response.

This study identifies α-synuclein's role in regulating inflammatory gene expression in melanoma cells through RNA sequencing and validation.

Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Expansion of human hematopoietic stem cells by inhibiting translation

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

Heparan sulfate dependent phase separation of CCL5 and its chemotactic activity

This study shows that CCL5 and heparan sulfate form phase-separated gradients, which guide immune cell migration, and demonstrates this through in vitro and in vivo experiments.

Multi-modal microvascular cerebral blood flow velocity mapping with 14T single-vessel MRI and optical microscopy in the mouse brain

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

Berberine impairs spermatogenesis in mice by modulating ornithine metabolism via gut microbiota regulation

This study shows berberine reduces sperm count and testosterone in mice by altering gut microbiota, specifically reducing Muribaculaceae, and affecting ornithine metabolism.