A. Bhardwaj

Transcription termination safeguards quiescent chromatin for faithful cell-cycle re-entry

This study shows that transcription termination by Ppn1 is essential for maintaining quiescent chromatin structure in fission yeast, ensuring faithful cell-cycle re-entry and preventing aneuploidy.

Curcumin Inhibits Zika Virus NS3 Helicase Activity

This study investigates curcumin's inhibitory effect on ZIKV NS3 helicase activity, finding it interacts with the enzyme and inhibits NTPase activity with an IC50 of 64.42 μM.

Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane Remodeling In Vivo

The paper shows how actin filaments dynamically adjust their structure to control membrane transfer between cellular compartments in live rodents.

Identification of a Hypoxia-induced Inflammatory Cell Death Pathway

The paper identifies a hypoxia-induced inflammatory cell death pathway involving PTP1B, RNF213, and CYLD/SPATA2, showing their role in tumor cell death and potential therapeutic targeting.

TERRA R-loops connect and protect sister telomeres in mitosis

This study shows that TERRA R-loops maintain sister telomere cohesion in mitosis, protecting cells from DNA damage and senescence by preventing resolution through tankyrase and C19orf43.

An efficient hairy root system for genome editing of a β-ODAP pathway gene in Lathyrus sativus

This paper develops a hairy root system for genome editing of the LsOCS gene in Lathyrus sativus to study its role in β-ODAP production and oxalate accumulation.

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

This paper introduces RIPTACs, a new class of heterobifunctional small molecules that selectively kill cancer cells by inducing protein-protein interactions that disrupt essential cellular functions.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

This study identifies plasma proteins associated with response to chemotherapeutic treatment in oesophageal adenocarcinoma using SWATH-MS and ELISA.

Bifidobacterium longum attenuates ovariectomy-induced bone loss via modulating the Immunoporotic Breg-Treg-Th17 cell axis

This study shows that Bifidobacterium longum reduces bone loss in ovariectomy-induced osteoporosis by modulating the Breg-Treg-Th17 immune axis.

Regulatory B cells (Bregs) inhibit osteoclastogenesis and prevent bone loss in osteoporotic mice model

This study shows that regulatory B cells (Bregs) inhibit osteoclastogenesis and reduce bone loss in a postmenopausal osteoporosis mouse model through IL-10 production.

Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice

This study shows that Lactobacillus rhamnosus reduces bone loss and improves bone health in Ovx mice by modulating Treg and Th17 cell balance and cytokine profiles.

Moyamoya Disease-Associated RNF213 Alleles Encode Dominant Negative Alleles That Globally Impair Ubiquitylation

This study identifies MMD-associated RNF213 SNPs as dominant negative alleles that impair ubiquitylation, suggesting reduced E3-ligase activity as central to MMD pathogenesis.

Escherichia coli β-clamp slows down DNA polymerase I dependent nick translation while accelerating ligation

This study shows that Escherichia coli β-clamp inhibits DNA polymerase I nick translation but promotes ligation during Okazaki fragment maturation.