Author

D. E. Scott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

A. R. Venkitaraman· 2 shared C. Abell· 2 shared G. Fischer· 2 shared G. McKenzie· 2 shared J. Skidmore· 2 shared R. Srinivasan· 2 shared T. L. Blundell· 2 shared T. Moschetti· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. R. Venkitaraman

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2 papers

Recent·Most cited

Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents

S. R. Stockwell, D. E. Scott, G. Fischer, E. Guarino, T. P. C. Rooney, T.-S. Fang, T. Moschetti, R. Srinivasan, E. Alza, A. Asteian, C. Dagostin, A. Alcaide, M. Rocaboy, B. Blaszczyk, A. Higueruelo, , M. Hyvönen

The paper develops selective Aurora A-TPX2 inhibitors that show in vivo efficacy and synergy with paclitaxel in pancreatic cancer.

bioRxiv · Mar 22, 2023 · PreprintBiochemistry

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

D. E. Scott, N. J. Francis-Newton, M. E. Marsh, A. G. Coyne, G. Fischer, T. Moschetti, A. R. Bayly, T. D. Sharpe, K. T. Haas, L. Barber, C. Valenzano, R. Srinivasan, D. J. Huggins, M. Ehebauer, A. Esposito, , C. Abell

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

bioRxiv · Jul 15, 2020Cancer Biology