A. R. Venkitaraman

The paper develops selective Aurora A-TPX2 inhibitors that show in vivo efficacy and synergy with paclitaxel in pancreatic cancer.

This study shows that a ketogenic diet slows tumor growth but accelerates cachexia and shortens survival in IL-6-driven cancer models by inducing ferroptosis and corticosterone deficiency.

The paper identifies small molecules that inhibit HIV-1 Nef's down-regulation of CD80/86, restoring T-cell activation by targeting the Nef-CD80 interface.

The paper shows that early neutrophilia driven by aerobic glycolysis supports host metabolism and delays cancer cachexia in murine models.

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

This paper introduces HDIM, a new imaging technique that enhances biochemical resolution in fluorescence microscopy by simultaneously quantifying multiple orthogonal properties of fluorescence emission.