G. Fischer

Targeting cancer with small molecule pan-KRAS degraders

A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.

Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents

The paper develops selective Aurora A-TPX2 inhibitors that show in vivo efficacy and synergy with paclitaxel in pancreatic cancer.

Breakdown in seasonal dynamics of subtropical ant communities with land-cover change

The paper examines how land-cover change affects seasonal ant activity patterns in subtropical forests, finding reduced seasonality and synchrony in more developed areas.

Consensus tandem tetratricopeptide repeat proteins are complex superhelical nanosprings

This study investigates the mechanical properties of consensus-designed tetratricopeptide repeats (CTPRs) using single-molecule techniques, revealing their spring-like behavior and superhelical structure.

SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes

The paper identifies mutations in SARS-CoV-2 that reduce MHC-I binding and CD8+ T cell recognition, suggesting escape from immune surveillance.

An evolutionary model identifies the main selective pressures for the evolution of genome-replication profiles.

The paper develops an evolutionary model to identify selective pressures shaping genome-replication profiles in yeast by analyzing replication origin dynamics.

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

Macroevolutionary integration of phenotypes within and across ant worker castes

The paper analyzes phenotypic integration patterns in ant worker castes across 246 species, finding mixed integration and rate heterogeneity in mesosoma and head shape evolution.

Evolution of the latitudinal diversity gradient in the hyperdiverse ant genus Pheidole

This study analyzes the latitudinal diversity gradient in the ant genus Pheidole, finding tropical conservatism explains the gradient rather than diversification rate variation.

The evolution of the temporal program of genome replication

The paper analyzes replication timing programs across ten Lachancea yeast species, finding linear evolution with divergence and high turnover of active replication origins.

Yeast de novo genes preferentially emerge from divergently transcribed, GC-rich intergenic regions

The paper identifies 703 de novo genes in 15 yeast species and finds they preferentially arise from GC-rich intergenic regions near divergent promoters and recombination hotspots.

Structure of the human pro-myostatin precursor and determinants of growth factor latency

This study determines the structure of human pro-myostatin and identifies features responsible for its latent state, offering insights into myostatin activation and potential inhibitor design.