Polyalanine disease mutations impair UBA6-dependent ubiquitination
F. Amer-Sarsour, D. Falik, Y. Berdichevsky, A. Kordonsky, G. Prag, G. Vatine, A. Ashkenazi
The paper shows polyalanine disease mutations disrupt UBA6-USE1 interactions, impairing ubiquitination and affecting synaptic protein levels in neurons.
bioRxiv · Jun 20, 2022 · PreprintCell Biology