Cell BiologybioRxivPreprint
Polyalanine disease mutations impair UBA6-dependent ubiquitination
F. Amer-Sarsour, D. Falik, Y. Berdichevsky…·A. Ashkenazi
The paper shows polyalanine disease mutations disrupt UBA6-USE1 interactions, impairing ubiquitination and affecting synaptic protein levels in neurons.