Loss of genome maintenance accelerates podocyte damage
F. Braun, A. M. Mandel, L. Blomberg, M. N. Wong, G. Chatzinikolaou, V. Nair, R. A. Akbar-Hase, V. G. Puelles, D. H. Meyer, P. J. McCown, F. Haas, M. Rahmatollahi, D. Fermin, G. Slaats, T. Bork, , C. E. Kurschat
This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.
bioRxiv · Sep 13, 2020 · PreprintCell Biology