Author

F. Braun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Microbiology· 2 Biophysics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Organism:bacteria (other)· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Trinquier· 2 shared C. Condon· 2 shared C. Prieto-Garcia· 2 shared M. E. Diefenbacher· 2 shared M. N. Wong· 2 shared M. Reissland· 2 shared O. Hartmann· 2 shared T. B. Huber· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. Trinquier

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Identification of a new substrate for the ribosome associated endoribonuclease Rae1 reveals a link to the B. subtilis response and sensitivity to chloramphenicol

V. Deves, A. Trinquier, L. Gilet, J. Alharake, M. Leroy, C. Condon, F. Braun

The paper identifies a new Rae1 cleavage site in the bmrBCD operon mRNA and links Rae1 activity to chloramphenicol resistance and translation quality control.

bioRxiv · Feb 16, 2023 · PreprintMicrobiology

Effect of tRNA maturase depletion on the levels and stabilities of ribosome assembly cofactor mRNAs in Bacillus subtilis

A. Trinquier, C. Condon, F. Braun

The paper examines how tRNA maturase depletion affects mRNA levels and stability of ribosome assembly cofactors in Bacillus subtilis, revealing complex transcriptional and post-transcriptional regulation.

bioRxiv · Nov 23, 2022 · PreprintMicrobiology

USP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.

C. Prieto-Garcia, O. Hartmann, M. Reissland, F. Braun, S. Bozkurt, C. T. Fuss, C. Schuelein-Voelk, A. Buchberger, M. A. Calzado, M. T. Rosenfeldt, I. Dikic, C. Muench, M. E. Diefenbacher

This study shows USP28 promotes lung cancer by stabilizing oncogenes and its inhibition enhances therapy for EGFR, BRAF, and PI3K mutant tumors.

bioRxiv · Sep 6, 2021Cancer Biology

Motile ghosts of the halophilic archaeon, Haloferax volcanii

Y. Kinosita, N. Mikami, Z. Li, F. Braun, T. E. Quax, C. v. d. Does, R. Ishmukhametov, S.-V. Albers, R. M. Berry

This study presents a membrane-permeabilized ghost system for Haloferax volcanii to investigate archaellum motility, revealing ATP selectivity, negative cooperativity, and a torque-speed curve with characteristics of both bacterial flagellar motors and F1-ATPase.

Proceedings of the National Academy of Sciences · Oct 13, 2020Peer-reviewedBiophysics

Loss of genome maintenance accelerates podocyte damage

F. Braun, A. M. Mandel, L. Blomberg, M. N. Wong, G. Chatzinikolaou, V. Nair, R. A. Akbar-Hase, V. G. Puelles, D. H. Meyer, P. J. McCown, F. Haas, M. Rahmatollahi, D. Fermin, G. Slaats, T. Bork, , C. E. Kurschat

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

bioRxiv · Sep 13, 2020 · PreprintCell Biology

Deep learning-based molecular morphometrics for kidney biopsies

M. Zimmermann, M. Klaus, M. N. Wong, A.-K. Thebille, L. Gernhold, C. Kuppe, M. Halder, J. Kranz, N. Wanner, F. Braun, S. Wulf, T. Wiech, U. Panzer, C. F. Krebs, E. Hoxha, , V. G. Puelles

The paper develops a deep learning method for analyzing kidney biopsy images to quantify podocyte loss, identifying morphometric signatures in ANCA-GN patients for risk stratification.

bioRxiv · Aug 23, 2020Pathology

Bioorthogonal red and far-red fluorogenic probes for wash-free live-cell and super-resolution microscopy

P. Werther, K. Yserentant, F. Braun, K. S. Grussmayer, V. Navikas, M. Yu, Z. Zhang, M. J. Ziegler, C. Mayer, A. J. Gralak, M. Busch, W. Chi, F. Rominger, A. Radenovic, X. Liu, , R. Wombacher

The paper develops new fluorogenic probes for live-cell and super-resolution microscopy with minimal label size and efficient quenching.

bioRxiv · Aug 7, 2020Cell Biology

The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours

C. Prieto-Garcia, O. Hartmann, M. Reissland, F. Braun, T. Fischer, S. Walz, A. Fischer, M. Calzado, A. Orian, M. Rosenfeldt, M. Eilers, M. E. Diefenbacher

This study identifies USP28 as a stabilizer of {Delta}Np63 in squamous cell carcinomas, showing that inhibiting USP28 reduces tumor growth and survival.

bioRxiv · Jun 27, 2019Cancer Biology