Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction
M. I. P. Ramos, L. Tian, E. J. de Ruiter, C. Song, A. Paucarmayta, A. Singh, E. Elshof, S. V. Vijver, J. Shaik, J. Bosiacki, Z. Cusumano, L. Liu, S. Langermann, S. Willems, D. Flies, L. Meyaard
The paper demonstrates that NC410, a LAIR-2 Fc protein, blocks LAIR-1-collagen interaction, enhancing T cell activity and reducing tumor growth in humanized models.
bioRxiv · Oct 21, 2020Cancer Biology