A. Singh

Decoy effect in shoaling decision making in zebrafish (Danio rerio)

This study examines the decoy effect in zebrafish shoaling decisions, finding sex-specific differences based on the order of choice presentation.

Promoting Human Intestinal Organoid Formation and Stimulation Using Piezoelectric Nanofiber Matrices

This study shows that piezoelectric nanofiber scaffolds promote faster spheroid formation and support intestinal organoid development without adverse effects.

Intestinal serotonergic vagal signaling as a mediator of microbiota-induced hypertension

This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.

Controlled and orthogonal partitioning of large particles into biomolecular condensates

This study demonstrates that large particles can be controlled and orthogonally partitioned into biomolecular condensates through strong particle-condensate interactions, using polymer nanoparticles with tailored surface chemistries.

Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species

This study identifies early transcriptional signatures of drug resistance in cancer and across species, showing conservation and predictive value for treatment response.

Glioma-associated tertiary lymphoid structures are sites of lymphocyte clonal expansion and plasma cell formation

The paper identifies tertiary lymphoid structures in gliomas as sites of immune response, showing they correlate with better survival and involve T and B cell clonal expansion and plasma cell formation.

Flagellar Motility is Mutagenic

This study shows that flagellar motility in E. coli increases mutation rates, suggesting it influences bacterial evolution rates.

Methemoglobin aggregation is modulated by the anti-sickling drug voxelotor

This study investigates how voxelotor affects methemoglobin aggregation at different pH levels, finding it enhances fiber formation at pH 5.5 but reduces aggregation at physiological pH 7.1.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Biomolecular Condensates Can Enhance Homotypic RNA Clustering

This study shows that repeat RNAs form nanoscale clusters within biomolecular condensates, driven by sequence features and RNA secondary structure, and that G3BP1 buffers these interactions.

Gram-positive bacteria are primed for surviving lethal doses of antibiotics and chemical stress

This study shows Gram-positive bacteria form primed cells that enable survival against antibiotics and chemical stress through epigenetic memory.

Programmable soft DNA hydrogels stimulate cellular endocytic pathways and proliferation

This paper develops DNA-based hydrogels that stimulate cellular endocytic pathways and proliferation by mimicking in vivo environments through programmable supramolecular structures.

Self-assembled DNA-collagen bioactive scaffolds promote cellular uptake and neuronal differentiation

This study develops self-assembled DNA-collagen scaffolds that enhance cellular uptake and promote neuronal differentiation of precursor cells.

Segatella copri strains adopt distinct roles within a single individual's gut

The paper isolates and compares 63 Segatella copri strains from a single gut microbiome, revealing phenotypic and host-microbe interaction differences.

Impedance-based assay for pan-cancer early and rapid detection of cell-free DNA

This paper introduces an impedance-based biosensor for rapid, label-free detection of cancer-associated cfDNA with high sensitivity and specificity across multiple cancer types.

Chloroquine Up-regulates Expression of SARS-CoV-2 receptor Angiotensin Converting Enzyme-2 in Endothelial Cells

This study shows chloroquine increases ACE2 expression in endothelial cells, potentially worsening SARS-CoV-2 infection in patients with cardiovascular or kidney diseases.

Molecular Matchmakers: Phytoplasma Effector SAP54 Targets MADS-Box Factor SVP to Enhance Attraction of Fecund Female Vectors by Modulating Leaf Responses to Male Presence

Spatial Transcriptomics in Bone Mechanomics: Exploring the Mechanoregulation of Fracture Healing in the Era of Spatial Omics.

This study uses spatial transcriptomics to analyze gene expression in relation to mechanical strain in fracture healing, identifying strain-dependent gene expression patterns.

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases

The paper identifies gut microbiota-associated bile salt hydrolases (BSHs) with distinct substrate preferences using chemoproteomic profiling.

Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice

This study examines daily metabolic and locomotor rhythms in prematurely ageing PolgA mice, finding sex-specific differences in activity and metabolic patterns.

Mitochondria drive microglial NRLP3 inflammasome activation via TSPO

This study shows TSPO on mitochondria promotes microglial inflammasome activation by stabilizing NLR proteins, inhibiting mitophagy, and enhancing pro-inflammatory gene expression, leading to excitotoxicity.

The transcription factor ATML1 maintains giant cell identity by inducing synthesis of its own (very) long-chain fatty acid-containing ligands

The paper shows that high ATML1 concentrations induce VLCFA synthesis, which maintains giant cell identity by promoting auto-activation through lipid ligand binding.

Unveiling shared genetic regulators for plant architectural and biomass yield traits in sorghum

This study identifies genetic loci and haplotypes associated with plant architectural and biomass yield traits in sorghum using genome-wide association studies and network analysis.

Bridging fungal resistance and plant growth through constitutive overexpression of Thchit42 gene in Pelargonium graveolens

This study overexpresses the Thchit42 gene in Pelargonium graveolens to enhance fungal resistance and plant growth, showing increased leaf size and oil content.

Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.

Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro .

This study shows that Mint/PDZ domains from non-bilaterian animals bind CaV2 channel C-termini in vitro, suggesting an ancient interaction with evolutionary changes in binding specificity.

Unveiling Frailty: Comprehensive and Sex-Specific Characterization in Prematurely Aging PolgA Mice

This study characterizes frailty in PolgA mice, showing sex-specific differences and parallels to human aging.

Experimental evolution for improved post-infection survival selects for increased disease resistance in Drosophila melanogaster

This study shows that experimental evolution of Drosophila melanogaster under post-infection survival selection leads to increased disease resistance but not disease tolerance.

Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy

This study identifies distinct growth and chaining properties in Clade 5 Clostridioides difficile strains using time-lapse microscopy, linked to the cmr switch sequence orientation.