Author

E. Elshof

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Meyaard· 2 shared A. J. Affandi· 1 shared A. Ottria· 1 shared A. Paucarmayta· 1 shared A. S. Meijers· 1 shared A. Singh· 1 shared B. Giovannone· 1 shared C. Song· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

L. Meyaard

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Author profile →

2 papers

Recent·Most cited

Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

T. Carvalheiro, W. Marut, M. I. Pascoal Ramos, S. Garcia, D. Fleury, A. J. Affandi, A. S. Meijers, B. Giovannone, R. G. Tieland, E. Elshof, A. Ottria, M. Cossu, M. L. Meizlish, T. Veenendaal, M. Ramanujam, , L. Meyaard

The paper investigates how impaired LAIR-1-collagen interaction in fibrosis contributes to inflammation and fibrosis, finding that dysfunctional collagen ligands and matrix metalloproteinases drive disease progression.

bioRxiv · Dec 7, 2021Immunology

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction

M. I. P. Ramos, L. Tian, E. J. de Ruiter, C. Song, A. Paucarmayta, A. Singh, E. Elshof, S. V. Vijver, J. Shaik, J. Bosiacki, Z. Cusumano, L. Liu, S. Langermann, S. Willems, D. Flies, L. Meyaard

The paper demonstrates that NC410, a LAIR-2 Fc protein, blocks LAIR-1-collagen interaction, enhancing T cell activity and reducing tumor growth in humanized models.

bioRxiv · Oct 21, 2020Cancer Biology