PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9
S. Kokane, P. Meier, A. Gulati, R. Matsuoka, T. Pipatpolkai, G. Albano, L. Delemotte, D. Fuster, D. Drew
This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.
bioRxiv · Sep 10, 2023 · PreprintBiochemistry