Author

D. Drew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 3 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:protein folding & dynamics· 4 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Gulati· 3 shared L. Delemotte· 3 shared C. Alleva· 2 shared D. Mitrovic· 2 shared G. Sun· 2 shared J. A. Neil· 2 shared J. Chen· 2 shared J. P. Tan· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

A. Gulati

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Author profile →

10 papers

Recent·Most cited

A CRISPR homing screen finds a chloroquine resistance transporter-like protein of the Plasmodium oocyst essential for mosquito transmission of malaria

A. Balakrishnan, M. Hunziker, P. Tiwary, V. Pandey, D. Drew, O. Billker

This study uses a CRISPR homing screen to identify essential genes for malaria transmission in mosquito stages, finding a chloroquine resistance transporter-like protein critical for oocyst development.

bioRxiv · Jun 2, 2024 · PreprintMicrobiology

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

M. L. Abramsson, R. A. Corey, J. L. Skerle, L. J. Persson, O. Anden, A. O. Oluwole, R. J. Howard, E. Lindahl, C. V. Robinson, K. Strisovsky, E. G. Marklund, D. Drew, P. J. Stansfeld, M. Landreh

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

bioRxiv · May 27, 2024Biochemistry

PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9

S. Kokane, P. Meier, A. Gulati, R. Matsuoka, T. Pipatpolkai, G. Albano, L. Delemotte, D. Fuster, D. Drew

This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.

bioRxiv · Sep 10, 2023 · PreprintBiochemistry

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

M. Currie, J. Davies, M. Scalise, A. Gulati, J. Wright, M. Newton-Vesty, G. Abeysekera, R. Subramanian, W. Wahlgren, R. Friemann, J. Allison, P. Mace, M. Griffin, B. Demeler, S. Wakatsuki, , R. North

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning

D. Mitrovic, S. E. McComas, C. Alleva, M. Bonaccorsi, D. Drew, L. Delemotte

The paper uses coevolution analysis and comparative modeling to predict the transport cycle states of the sugar porter superfamily and defines molecular determinants of the cycle.

bioRxiv · Sep 24, 2022Biophysics

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2

R. Rudraraju, M. J. Gartner, J. A. Neil, E. S. Stout, J. Chen, E. J. Needham, M. See, C. Mackenzie-Kludas, L. Y. Yang, M. Wang, H. Pointer, K. Karavendzas, D. Abu-Bonsrah, D. Drew, Y. B. Y. Sun, , K. Subbarao

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

bioRxiv · Sep 20, 2022 · PreprintMicrobiology

Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5

S. McComas, T. Reichenbach, D. Mitrovic, C. Alleva, M. Bonaccorsi, L. Delemotte, D. Drew

This study shows GLUT5 transitions through an occluded state similar to PfHT1, with fructose binding lowering energetic barriers and enabling fast sugar flux through allosteric coupling.

bioRxiv · Jun 17, 2022Biophysics

An iTSC-derived placental model of SARS-CoV-2 infection unveils ACE2-dependent susceptibility in syncytiotrophoblasts

J. Chen, J. A. Neil, J. P. Tan, R. Rudraraju, M. Mohenska, Y. B. Sun, G. Sun, Y. Zhou, Y. Li, D. Drew, P. Pymm, W.-H. Tham, F. J. Rossello, G. Nie, X. Liu, , J. M. Polo

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

bioRxiv · Oct 27, 2021 · PreprintCell Biology

Structure and lipid-mediated remodelling mechanism of the Na+/H+ exchanger NHA2

R. Matsuoka, R. Fudim, S. Jung, C. Zhang, A. Bazzone, Y. Chatzikyriakidou, N. Nomura, S. Iwata, L. Orellana, O. Beckstein, D. Drew

This paper reports the cryo-EM structures of NHA2 and reveals its lipid-mediated dimerization mechanism for ion exchange.

bioRxiv · Jul 22, 2021 · PreprintBiophysics

Structural basis for the delivery of activated sialic acid into Golgi for sialyation

E. Nji, A. Gulati, A. A. Qureshi, M. Coincon, D. Drew

This study determines the crystal structure of a CMP-sialic acid transporter complexed with CMP, revealing its mechanism of CMP-sialic acid recognition and translocation across Golgi membranes.

bioRxiv · Mar 17, 2019Biochemistry