P. Meier

Kinases in motion: impact of protein and small molecule interactions on kinase conformations

This study uses KinCon-reporter technology to analyze conformational changes in disease-associated kinases upon drug, regulatory protein, and pathway activation interactions, revealing insights into therapeutic strategies.

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

PI-(3,5)P2-mediated oligomerization of the endosomal sodium/proton exchanger NHE9

This study reports cryo-EM structures of NhaA and NHE9 with lipid binding at the dimer interface, showing PI(3,5)P2 stabilizes NHE9 oligomerization and enhances activity.

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

This study shows that cleavage of cFLIP by Caspase-8 limits cell death during viral infection and tissue injury, promoting tissue repair.

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

drICE restrains DIAP2-mediated inflammatory signalling and intestinal inflammation

The paper shows that drICE inhibits DIAP2-mediated NF-κB signaling and intestinal inflammation by cleaving DIAP2, preventing its pro-inflammatory activity without affecting pathogen-induced responses.

Myc supercompetitor cells exploit the NMDA receptor to subdue their wild-type neighbours via cell competition

The paper shows Myc-expressing cells use NMDA receptors to outcompete wild-type cells, and inhibiting these receptors makes them losers in cell competition.