Store-operated Ca2+ entry regulatory factor (SARAF) alters murine metabolic state in an age-dependent manner via hypothalamic pathways.
D. Gataulin, Y. Kuperman, M. Tsoory, I. Biton, I. Karbat, A. Meshcheriakova, E. Reuveny
This study shows SARAF deficiency causes age-dependent obesity, reduced metabolic rate, and behavioral changes, with protective effects when SARAF is removed from the hypothalamus.
bioRxiv · Aug 3, 2022 · PreprintPhysiology