Author

I. Karbat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:electrophysiology· 3 Approach:biophysical modeling· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:behavioral assay· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Reuveny· 5 shared C. Saikia· 2 shared D. Gordon· 2 shared H. Altman-Gueta· 2 shared O. Dym· 2 shared A. Goldenzweig· 1 shared A. Meshcheriakova· 1 shared D. Gataulin· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersPharmacology & Toxicology

E. Reuveny

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Comment on 'Connexins evolved after early chordates lost innexin diversity'

I. V. Kelmanson, E. A. Bakin, I. Karbat, G. A. Slivko-Koltchik, E. Reuveny, Y. V. Panchin

The paper shows that reported connexin and innexin sequences from echinoderms are cross-species contaminations, refuting the existence of a third GJ protein family in these organisms.

bioRxiv · Jan 5, 2023 · PreprintEvolutionary Biology

One-shot design elevates functional expression levels of a voltage-gated potassium channel

J. J. Weinstein, C. Saikia, I. Karbat, A. Goldenzweig, E. Reuveny, S. J. Fleishman

The paper introduces mPROSS, an algorithm that improves the functional expression of membrane proteins through one-shot design, achieving up to 14-fold increase in current densities without altering single-channel activity.

bioRxiv · Dec 28, 2022Biochemistry

Store-operated Ca2+ entry regulatory factor (SARAF) alters murine metabolic state in an age-dependent manner via hypothalamic pathways.

D. Gataulin, Y. Kuperman, M. Tsoory, I. Biton, I. Karbat, A. Meshcheriakova, E. Reuveny

This study shows SARAF deficiency causes age-dependent obesity, reduced metabolic rate, and behavioral changes, with protective effects when SARAF is removed from the hypothalamus.

bioRxiv · Aug 3, 2022 · PreprintPhysiology

A molecular lid mechanism of K+ channelblocker action revealed by a cone peptide

C. Saikia, O. Dym, H. Altman-Gueta, D. Gordon, E. Reuveny, I. Karbat

The paper investigates two cone peptides' mechanisms of blocking K+ channels in Drosophila Shaker, revealing a 'molecular lid' mechanism for one peptide.

bioRxiv · Jun 15, 2020Pharmacology & Toxicology

Pore-modulating toxins exploit inherent slow inactivation to block K+ channels

I. Karbat, H. Altman-Gueta, S. Fine, T. Szanto, S. Hamer-Rogotner, O. Dym, F. Frolow, D. Gordon, G. Panyi, M. Gurevitz, E. Reuveny

The paper shows that the toxin Cs1 blocks K+ channels by modulating pore structure through hydrogen bond disruption, leading to asymmetric pore collapse.

bioRxiv · Mar 13, 2019Pharmacology & Toxicology