Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein
D. Glon, G. Vilmen, D. Perdiz, E. Hernandez, G. Beauclair, F. QUIGNON, C. Berlioz-Torrent, V. Maréchal, C. Poüs, M. Lussignol, A. Esclatine
This study shows that EBV's BHRF1 protein induces microtubule hyperacetylation to form mito-aggresomes, blocking IFN signaling and promoting viral survival.
bioRxiv · Jun 11, 2021Cell Biology