G. Beauclair

Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF- κB pathway towards SARS-CoV-2

The paper analyzes transcriptomic data from sorted SARS-CoV-2 infected lung cells to show the NF-κB pathway promotes viral replication while CYLD inhibits it.

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

The paper identifies twenty-one host genes that modulate flavivirus replication in an interferon-dependent manner using siRNA screening in ZIKV-infected microglial cells.

Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein

This study shows that EBV's BHRF1 protein induces microtubule hyperacetylation to form mito-aggresomes, blocking IFN signaling and promoting viral survival.

RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus

This study identifies RIG-I and PKR as key mediators of the pro-inflammatory response to YFV in hepatocytes, showing that stress granules are not required for cytokine induction.

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti

This study shows that YFV-17D replicates inefficiently in Aedes aegypti midgut and fails to disseminate, unlike a clinical isolate, due to midgut barriers.