IL-12 signaling promotes TET2-mediated DNA demethylation during CD8 T cell effector differentiation
C. Zebley, H. Abdelsamed, H. Ghoneim, S. Alli, D. Haydar, T. Harris, M. Mcgargill, G. Krenciute, B. Youngblood
This study shows IL-12 signaling promotes TET2-mediated DNA demethylation at the IFNg locus during CD8 T cell effector differentiation, enhancing IFNg expression.
bioRxiv · Nov 2, 2020 · PreprintImmunology