T. Harris

The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta.

This study investigates the role of placental BPGM in fetal growth restriction using mouse models and human placental analysis, finding altered BPGM expression and 2,3 BPG levels in hypoxic conditions.

A mechanistic switch from selective transporter to an ion channel impairs the filamentation signalling capability of ammonium transceptors in yeast

The paper shows that variations in the Twin-His motif of Amt-Mep transporters switch their function from selective transport to non-specific ion channel activity, impairing filamentation signaling in yeast.

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure

The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.

Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material

The paper shows that Arp2/3 networks induce smooth interfaces between actomyosin networks through mechanosensitive contractility, both in simulations and in vivo.

IL-12 signaling promotes TET2-mediated DNA demethylation during CD8 T cell effector differentiation

This study shows IL-12 signaling promotes TET2-mediated DNA demethylation at the IFNg locus during CD8 T cell effector differentiation, enhancing IFNg expression.

Stalling chromophore maturation of the fluorescent protein Venus reveals the molecular basis of the final oxidation step

The paper identifies the molecular mechanism of the final oxidation step in Venus fluorescent protein maturation by using crystal structures and spectroscopy.

Coadaptation of the chemosensory system with voluntary exercise behavior in mice

This study shows that selective breeding for voluntary wheel running in mice leads to genetic differentiation in the vomeronasal organ, suggesting chemosensory receptors as quantitative trait loci for exercise behavior.

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

IL-10 and ICOS differentially regulate T cell responses in the brain during chronic Toxoplasma gondii infection

This study investigates how IL-10 and ICOS differentially regulate T cell responses in the brain during chronic Toxoplasma gondii infection, showing distinct effects on inflammation and T cell dynamics.