High-resolution lung adenocarcinoma expression subtypes identify tumors with dependencies on MET, CDK4, CDK6, and PD-L1
W. Roh, Y. Geffen, M. Miller, S. Anand, J. Kim, D. Heiman, J. F. Gainor, P. W. Laird, A. D. Cherniack, National Cancer Institute Center for Cancer Genomics Tumor Molecular Pathology (TMP) AWG, G. Getz
The paper identifies five lung adenocarcinoma expression subtypes using consensus hierarchical clustering and finds subtype-specific dependencies on MET, CDK4, CDK6, and PD-L1, which could guide targeted therapies.
bioRxiv · Feb 20, 2022 · PreprintCancer Biology