M. Miller

Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

The paper identifies three new small molecule agonists for NPYLR7 that suppress mosquito blood feeding at lower doses than previous compounds.

Using a function-first "scout fragment"-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

The paper develops covalent inhibitors for conformationally dynamic helicases using electrophilic scout fragments and a function-first approach, targeting SARS-CoV-2 nsp13 and human helicases BLM and WRN.

Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook

The paper identifies lysinoalanine (Lal) crosslinks in spirochete flagellar hooks across multiple species, showing they are conserved and necessary for motility.

BrainLine: An Open Pipeline for Connectivity Analysis of Heterogeneous Whole-Brain Fluorescence Volumes

BrainLine processes whole-brain fluorescence images through registration, segmentation, and analysis using a feedback-based training approach.

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

The paper analyzes single-cell data to understand gene regulation in stem cell-derived pancreatic islets and identifies factors affecting beta-cell maturation and proliferation.

Quantitative bioactivity signatures of dietary supplements and natural products

The paper screens dietary supplements and natural products for bioactivity using in vitro assays and predicts their mechanisms of action by comparing activity profiles with approved drugs.

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer's Disease

The paper aligns 2D histology images of AD pathology with 3D MRI to reconstruct NFT density in the MTL, finding high NFT density in the rostral hippocampus and adjacent regions.

High-resolution lung adenocarcinoma expression subtypes identify tumors with dependencies on MET, CDK4, CDK6, and PD-L1

The paper identifies five lung adenocarcinoma expression subtypes using consensus hierarchical clustering and finds subtype-specific dependencies on MET, CDK4, CDK6, and PD-L1, which could guide targeted therapies.

Histone H4K20 Trimethylation is Decreased in Murine Models of Heart Disease

This study examines histone H4K20 trimethylation in murine heart disease models, finding biphasic regulation and identifying enzymes involved in its modification.

Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine.

This study shows that ETEC's EatA protein degrades the host MUC2 mucin barrier, enabling bacterial access to enterocytes and toxin delivery.

Niclosamide reverses SARS-CoV-2 control of lipophagy

This study shows niclosamide reduces SARS-CoV-2 replication by modulating lipophagy and lipid metabolism in infected cells.

RT-QuIC amplification of CWD prions in winter ticks (Dermacentor albipictus) collected from North American elk (Cervus canadensis) in a CWD-endemic area

The paper detects amplifiable CWD prions in winter ticks from elk using RT-QuIC, with prions found in ticks from both advanced and mid-stage CWD-infected elk.

Identification of candidate susceptibility genes to Puccinia graminis f. sp. tritici in wheat

The paper identifies candidate susceptibility genes to wheat stem rust disease by analyzing gene expression changes in susceptible and resistant wheat genotypes and a non-host plant.

An epigenetic switch regulates the ontogeny of AXL positive/EGFR-TKI resistant cells by modulating miR-335 expression

The paper identifies an epigenetic mechanism regulating AXL-positive/Erlotinib-resistant cells through miR-335 expression, suggesting combinatorial therapies for EGFR-mutated NSCLC.

A Library Of Induced Pluripotent Stem Cells From Clinically Well-Characterized, Diverse Healthy Human Individuals

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms

This study evaluates a new antibiotic, CZ-01179, against biofilms using in vitro methods and finds it more effective than current standards in eradicating mature biofilms.

Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent

This study measures the myosin super-relaxed state (SRX) in human skeletal muscle fibers, finding fiber-type dependent differences in SRX fraction and ATP turnover.

Open source software tool for the automated detection and characterization of epithelial cells from trace biological samples

The paper introduces an open-source tool for automated detection and characterization of epithelial cells in microscopic images, improving throughput and reproducibility.

Phylo-comparative analyses reveal the dual role of drift and selection in reproductive character displacement.

The paper uses phylo-comparative methods and genomic data to show that reproductive character displacement in two cricket species is driven by both drift and selection, leading to speciation.

Detection of race-specific resistance against Puccinia coronata f. sp. avenae in Brachypodium species

The paper examines resistance to Puccinia coronata f. sp. avenae in Brachypodium species, finding race-specific responses independent of ROS and involving salicylic acid and ethylene signaling.

Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation

The paper identifies Hv1 and CatSper nanodomains in human sperm that regulate flagellar rotation and hyperactivated motility through asymmetric positioning.

A near complete haplotype-phased genome of the dikaryotic wheat stripe rust fungus Puccinia striiformis f. sp. tritici reveals high inter-haplotype diversity

This paper presents a haplotype-phased genome assembly of the wheat stripe rust fungus, revealing high inter-haplotype diversity and novel genomic features associated with virulence.

Raspberry Pi Powered Imaging for Plant Phenotyping

This paper describes three low-cost Raspberry Pi-based imaging platforms for plant phenotyping, enabling high-throughput data collection and analysis using open-source tools.