The TIM22 complex regulates mitochondrial one-carbon metabolism by mediating the import of Sideroflexins
D. Stojanovski, T. D. Jackson, D. Hock, C. Palmer, Y. Kang, K. Fujihara, N. Clemons, D. Thorburn, D. A. Stroud
This study identifies Sideroflexins as substrates of the TIM22 complex and shows their role in mitochondrial one-carbon metabolism, linking AGK dysfunction to Sengers syndrome.
bioRxiv · Feb 6, 2020Cell Biology