C. Palmer

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

On the hindlimb biomechanics of the avian take-off leap

This study simulates the hindlimb biomechanics of zebra finches during take-off, finding that muscles can generate sufficient force to balance external moments at the hip, knee, and ankle.

Mapping enzyme catalysis with metabolomic biosensing

The paper introduces a method to sense enzyme product formation using host cell metabolism and mass spectrometry to map enzyme activity and mutagenesis effects.

Novel virus-like particle vaccine encoding the circumsporozoite protein of Plasmodium falciparum is immunogenic and induces functional antibody responses

This paper describes a novel virus-like particle vaccine using duck hepatitis B virus surface antigen to display Plasmodium falciparum CSP, showing improved immunogenicity and functional antibody responses in mice.

Phospholipid Metabolism Is Associated with HIV Rebound Upon Treatment Interruption

This study links phospholipid and lysophospholipid levels to faster HIV rebound after treatment interruption, suggesting their role in viral persistence and inflammation.

Direct information estimation from cryo-EM Movies with CARYON

This study measures information content in cryo-EM movies to improve parameter estimation for 3D reconstruction, introducing the CARYON filter for enhanced image processing.

Rearing medium dictates variability across replicates in untreated and arsenic challenged zebrafish larvae

This study shows that rearing medium affects gene expression variability and iAs toxicity in zebrafish larvae, highlighting the need for standardized experimental conditions.

Outcomes of the 2019 EMDataResource model challenge: validation of cryo-EM models at near-atomic resolution

The paper evaluates cryo-EM model quality using benchmark maps, showing high accuracy and reproducibility across 13 teams and recommending multiple metrics for model assessment.

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

The TIM22 complex regulates mitochondrial one-carbon metabolism by mediating the import of Sideroflexins

This study identifies Sideroflexins as substrates of the TIM22 complex and shows their role in mitochondrial one-carbon metabolism, linking AGK dysfunction to Sengers syndrome.

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine.

The paper uses ex vivo lung organocultures and patient genomics to identify genetic predictors of drug response in COPD.

Active Trachoma Cases In The Solomon Islands Have Varied Polymicrobial Community Structures But Do Not Associate With Individual Non-Chlamydial Pathogens Of The Eye

The paper investigates whether active trachoma in the Solomon Islands is linked to non-chlamydial pathogens or polymicrobial dysbiosis, finding no significant association with individual pathogens but noting inter-individual microbiome variation.