Y. Kang

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

Structural Basis for the Activation of Proteinase-Activated Receptors (PARs) by Endogenous Ligands

This study presents structural insights into PAR1 and PAR2 activation by endogenous ligands, revealing a novel mechanism and potential targets for therapeutic development.

A Multitrait Genome-Wide Association Study Reveals a Requirement for the Strigolactone Receptor DWARF14 in Optimal GOLVEN10 Signaling

This study identifies a genetic link between strigolactone signaling and GLV10 responsiveness in Medicago truncatula through genome-wide association and mutant analysis.

Structural basis of bulk lipid transfer by bridge-like lipid transfer protein LPD-3

This study determines the structure of the LPD-3 BLTP complex and reveals its mechanism for bulk lipid transfer through interactions with Intake and Spigot proteins.

Abo1 ATPase facilitates the dissociation of FACT from chromatin.

This study identifies Abo1 as a histone chaperone that facilitates FACT dissociation from chromatin through an ATP-dependent mechanism, essential for heterochromatin maintenance.

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

Seminal root angle is associated with root system architecture in durum wheat

This study examines the relationship between seminal root angle and root system architecture in durum wheat, showing distinct RSA patterns in wide and narrow genotypes at later growth stages.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

Intraoperative Bioprinting of Human Adipose-derived Stem cells and Extra-cellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation during Full-thickness Craniomaxillofacial Skin Reconstruction

This study uses intraoperative bioprinting of human adipose-derived stem cells and extracellular matrix to reconstruct full-thickness skin defects in rats, achieving wound closure and hair follicle-like structures within two weeks.

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation

This study identifies kinases regulating KSHV reactivation using a polypharmacology-based screen, revealing both pro-lytic and latency-promoting kinases.

Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-specific inflammation

The paper identifies a Muc4-expressing metaplastic gastric cell type in mice driven by H. pylori inflammation and shows its association with proliferation in human gastric cancer.

A Fast Solution for Automated Single-Molecule Force Spectroscopy Data Collection and Processing

The paper develops an automated software tool for processing single-molecule force spectroscopy data, improving efficiency and reducing errors in fitting force-extension curves.

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

This study compares chromatin remodeling in colorectal cancer patient-derived models and identifies transcription factors driving differences in growth and drug response.

Identification of ASPDH as a novel NAADP-binding protein

The paper identifies ASPDH as a novel NAADP-binding protein through biochemical purification and ITC experiments, showing specific binding with a Kd of 455 nM, unlike previously identified NAADP-receptors.

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex

The paper presents the cryo-EM structure of the NALCN-FAM155A-UNC79-UNC80 channel complex and elucidates its assembly and regulatory mechanisms.

Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-induced Myeloid-Derived Suppressor Cells

This study identifies CaMKK2 as a regulator of MDSC expansion, showing its inhibition reduces tumor growth and enhances antitumor immunity.

Interactions among rooting traits for deep water and nitrogen uptake in upland and lowland ecotypes of switchgrass (Panicum virgatum L.)

This study examines root trait interactions and deep nitrate capture in switchgrass ecotypes under water and nitrogen stress, finding shared and distinct responses and a link between deep rooting and aboveground growth.

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

The effect of Basal core promoter and pre-core mutations on HBV replication and persistence in mice

This study shows that BCP and Pre-C mutations in HBV increase viral replication but reduce immune tolerance, with Pre-C mutations causing more severe immune responses and shorter viral persistence in mice.

A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASIS

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

The paper reports the cryo-EM structure of the NALCN-FAM155A complex, revealing its sodium selectivity, voltage modulation, and disease-related mutation sites.

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

The paper determines cryo-EM structures of human TRPC5 channel with two inhibitors, revealing their distinct binding sites and mechanisms of action.

The TIM22 complex regulates mitochondrial one-carbon metabolism by mediating the import of Sideroflexins

This study identifies Sideroflexins as substrates of the TIM22 complex and shows their role in mitochondrial one-carbon metabolism, linking AGK dysfunction to Sengers syndrome.

Surface association induces cytotoxic alkyl-quinolones in Pseudomonas aeruginosa

This study identifies alkyl-quinolones as surface-induced cytotoxins in Pseudomonas aeruginosa and shows their role in virulence regulation.

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

This study determines the structure of human SOAT1 using cryo-EM and reveals how the inhibitor CI-976 blocks the active site.

YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

Structural insights into the mechanism of the human soluble guanylate cyclase

This study reports cryo-EM structures of human sGC 1β1 heterodimer in different states, revealing the structural mechanism of NO-induced activation.