Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types
A. Miar, E. Arnaiz, E. Bridges, S. Beedie, A. P. Cribbs, D. J. Downes, R. Beagrie, J. Rehwinkel, A. L. Harris
This study shows hypoxia reduces type I IFN pathway activity in cancer cells through transcriptional and chromatin changes, independent of HIF1/2.
bioRxiv · Jul 25, 2019Cancer Biology