A. L. Harris

APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes

The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.

Large-pore connexin hemichannels function as molecule transporters independently of ion conduction

The paper shows that connexin hemichannels can transport molecules independently of ion conduction, challenging the conventional view of their function.

Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

This paper shows that stress-induced Rab11a-exosomes carrying AREG promote cetuximab resistance in colorectal cancer by activating EGFR signaling in KRAS-wild type cells.

A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells

The paper studies DCG biogenesis in Drosophila secondary cells, identifying a Rab6 to Rab11 transition essential for DCG and exosome formation.

LARP1 regulates metabolism and mTORC1 activity in cancer

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

Anti-androgens induce Rab11a-exosome secretion in prostate cancer by suppressing amino acid-sensitive PAT4-mTORC1 signalling

This study shows anti-androgens increase Rab11a-exosome secretion in prostate cancer by inhibiting PAT4-mTORC1 signaling, contributing to drug resistance.

Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription

The paper shows hypoxia reduces mitochondrial double-stranded RNA production in breast cancer cells, leading to decreased type I IFN signaling and immunosuppression.

Accessory ESCRT-III proteins selectively regulate Rab11-exosome biogenesis in Drosophila secondary cells

This study identifies accessory ESCRT-III proteins as essential for Rab11-exosome biogenesis in Drosophila secondary cells, distinct from core ESCRT functions.

A novel voltage clamp/dye uptake assay reveals saturable transport of molecules through CALHM1 and connexin channels.

The paper develops a TEVC/dye uptake assay to study molecular transport through CALHM1 and connexin channels, revealing saturable kinetics and voltage-dependent behavior.

Glutamine deprivation regulates the origin and function of cancer cell exosomes

This study shows that glutamine deprivation increases exosome release from cancer cells, which promote tumor growth and blood vessel networks through Rab11a-dependent mechanisms.

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

This study shows hypoxia reduces type I IFN pathway activity in cancer cells through transcriptional and chromatin changes, independent of HIF1/2.

Radiation resistant cancer cells enhance the survival and resistance of sensitive cells in prostate spheroids

This study shows radiation-resistant prostate cancer cells enhance survival and resistance of sensitive cells in spheroids through competitive and antagonistic interactions.

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine-resistance in breast cancer

This study shows hypoxia shifts SNAT2 regulation from ER to HIF-1 in breast cancer, leading to endocrine resistance and poor outcomes.