Author

A. Miar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. L. Harris· 3 shared E. Arnaiz· 2 shared J. Rehwinkel· 2 shared A. Biroccio· 1 shared A. G. Dias· 1 shared A. Harris· 1 shared A. Londono· 1 shared A. P. Cribbs· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

A. L. Harris

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4 papers

Recent·Most cited

Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription

E. Arnaiz, A. Miar, A. G. Dias, N. Prasad, U. Schulze, D. Waithe, J. Rehwinkel, A. L. Harris

The paper shows hypoxia reduces mitochondrial double-stranded RNA production in breast cancer cells, leading to decreased type I IFN signaling and immunosuppression.

bioRxiv · Jul 31, 2020Cancer Biology

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

A. Miar, E. Arnaiz, E. Bridges, S. Beedie, A. P. Cribbs, D. J. Downes, R. Beagrie, J. Rehwinkel, A. L. Harris

This study shows hypoxia reduces type I IFN pathway activity in cancer cells through transcriptional and chromatin changes, independent of HIF1/2.

bioRxiv · Jul 25, 2019Cancer Biology

Radiation resistant cancer cells enhance the survival and resistance of sensitive cells in prostate spheroids

P. Kannan, M. Paczkowski, A. Miar, J. Owen, W. W. Kretzschmar, S. Lucotti, J. Kaeppler, J. Chen, B. Markelc, L. A. Kunz-Schughart, A. L. Harris, M. Partridge, H. Byrne

This study shows radiation-resistant prostate cancer cells enhance survival and resistance of sensitive cells in spheroids through competitive and antagonistic interactions.

bioRxiv · Mar 3, 2019 · PreprintCancer Biology

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

T. Reislander, E. Puig Lombardi, F. J. Groelly, A. Miar, M. Porru, B. Wright, H. Lockstone, A. Biroccio, A. Harris, A. Londono, M. Tarsounas

This study shows that BRCA2 loss in cancer cells triggers innate immune responses, which are enhanced by PARP inhibitors, suggesting a mechanism for their therapeutic effect.

bioRxiv · Dec 10, 2018Cancer Biology