Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms
C. McClenaghan, A. Hanson, M. Sala-Rabanal, H. I. Roessler, D. Josifova, D. K. Grange, G. van Haaften, C. G. Nichols
This study investigates how specific SUR2 mutations in Cantu Syndrome alter KATP channel function through different mechanisms, with implications for drug response.
bioRxiv · Oct 26, 2017Biophysics