Author

D. Koch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Alexandrovich· 1 shared A. Beavil· 1 shared A. Fukuzawa· 1 shared A. L. Kho· 1 shared M. Gautel· 1 shared M. Pfuhl· 1 shared M. Rees· 1 shared S. Ponnam· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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1 shared paperBiochemistry

A. Alexandrovich

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2 papers

Recent·Most cited

The cardiac myosin binding protein-C phosphorylation state as a function of multiple protein kinase and phosphatase activities

T. Kampourakis, S. Ponnam, D. Koch

This study characterizes cMyBP-C dephosphorylation by PP1 and PP2A and develops a kinetic model showing site-specific and hierarchical phosphatase action opposite to kinase phosphorylation.

bioRxiv · Feb 24, 2023Biochemistry

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro

D. Koch, A. L. Kho, A. Fukuzawa, A. Alexandrovich, A. Beavil, M. Pfuhl, M. Rees, M. Gautel

The paper investigates obscurin GEF domains, showing they are phosphorylated by MST-family kinases but lack detectable nucleotide exchange activity towards Rho GTPases in vitro.

bioRxiv · Oct 14, 2022 · PreprintBiochemistry