Signaling from the RNA sensor RIG-I is regulated by ufmylation
D. L. Snider, M. Park, K. A. Murphy, D. C. Beachboard, S. M. Horner
This paper shows that ufmylation, mediated by UFL1, promotes RIG-I signaling by facilitating its interaction with 14-3-3ε and MAVS, enhancing IFN induction during RNA virus infection.
bioRxiv · Oct 26, 2021Immunology