M. Park

Hidden route of protein damage through confined oxygen gas

The paper identifies a hidden oxidative damage pathway in proteins through O2 confinement and photoexcitation, bypassing antioxidant defenses.

A Near Infrared Fluorescent Nanosensor for Spatial and Dynamic Measurements of Auxin, Indole-3-Acetic Acid, in Planta

This paper introduces a near infrared fluorescent nanosensor for spatial and dynamic measurement of IAA in planta, showing species independence and functionality in plant cells.

de Novo Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 Vaccination

This paper presents a method to sequence polyclonal IgG antibodies from human plasma post-SARS-CoV-2 vaccination, generating recombinant antibodies with neutralizing capabilities.

Forest and Biodiversity 2: a tree diversity experiment to understand the consequences of multiple dimensions of diversity and composition for long-term ecosystem function and resilience

The paper introduces a long-term tree diversity experiment to study how species diversity and composition affect ecosystem function and resilience, with findings showing higher mortality in monocultures and the importance of diversity in reducing tree mortality.

ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function

This study classifies ADPKD-causing missense variants in polycystin-1 into two categories based on their effects on cell surface localization or ion channel function and suggests small-molecule therapies.

Live Malassezia strains isolated from the mucosa of patients with ulcerative colitis

This study isolates and characterizes live Malassezia globosa strains from ulcerative colitis patients' intestinal mucosa, showing they exacerbate colitis in mice and exhibit hypoxia adaptation.

Cellular RNA interacts with MAVS to promote antiviral signaling

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

Sulfasalazine promotes myogenic differentiation via increasing of fast myosin heavy chain isoforms

This study shows sulfasalazine promotes myogenic differentiation by increasing fast myosin heavy chain isoforms through a metabolic shift to glycolysis in C2C12 myoblasts and improves muscle function in aged and injured mice.

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation

This paper develops APB-R3, a long-acting IL-18 blocker, showing efficacy in reducing inflammation in macrophage activation syndrome and atopic dermatitis models.

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway.

PD-L1 promotes oncolytic virus infection by inhibiting the type I interferon pathway through a metabolic shift involving enhanced glycolysis and lactate production.

Loop stacking organizes genome folding from TADs to chromosomes

This study uses super-resolution microscopy to show that CTCF and cohesin organize chromatin loops at the single-cell level, influencing genome folding and gene expression variability.

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.

Development of fluoroquinolone resistance through antibiotic tolerance in Campylobacter jejuni

This study shows that antibiotic tolerance in Campylobacter jejuni induced by ciprofloxacin and tetracycline leads to rapid development of fluoroquinolone resistance.

NSF/αSNAP2-mediated cis-SNARE complex disassembly precedes membrane fusion generating the cell plate during Arabidopsis cytokinesis

The paper identifies NSF/αSNAP2 as the machinery disassembling KNOLLE cis-SNARE complexes during Arabidopsis cytokinesis, preceding cell plate formation.

Nucleocapsid-specific humoral responses improve the control of SARS-CoV-2

This study shows that nucleocapsid-specific antibodies can help control SARS-CoV-2 infection in mice, suggesting their potential inclusion in vaccines and monoclonal therapies.

Met-HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells

The paper identifies a HER3-MPZL3 axis that supports proliferation in MET-amplified cancer cells through tyrosine phosphorylation and interaction.

Signaling from the RNA sensor RIG-I is regulated by ufmylation

This paper shows that ufmylation, mediated by UFL1, promotes RIG-I signaling by facilitating its interaction with 14-3-3ε and MAVS, enhancing IFN induction during RNA virus infection.

Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits

This study identifies ALPPL2 as a tumor-specific antigen and demonstrates that synNotch CAR T cells targeting it improve tumor control by reducing T cell exhaustion.

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

Identification of stromal genes differentially expressed in lobular breast cancer highlights role for pregnancy-associated-plasma protein-A

The paper identifies stromal genes differentially expressed in lobular breast cancer, highlighting pregnancy-associated-plasma protein-A (PAPPA) as a potential prognostic marker.

Integrated Micropillar Polydimethylsiloxane Accurate CRISPR Detection (IMPACT) System for Rapid Viral DNA Sensing

The paper develops an IMPACT system for rapid viral DNA detection using CRISPR, achieving sensitivity from 0.1 to 10 nM without fluorescent quenchers.

mTOR-driven widespread exon skipping renders multifaceted gene regulation and proteome complexity

This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.

Single Chlamydomonas reinhardi (C. reinhardtii) cell separation from bacterial cells and auto-fluorescence tracking with a nano-sieve device

This paper develops a nano-sieve device for separating microalgae from bacteria and tracking single cells via auto-fluorescence.

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

Multiplex generation, tracking, and functional screening of substitution mutants using a CRISPR/retron system

This paper develops a CRISPR/retron system for high-throughput generation and tracking of substitution mutations in E. coli, enabling genome-scale screening of chemical responses and fitness changes.

A novel virus alters gene expression and vacuolar morphology in Malassezia cells and induces a TLR3-mediated inflammatory immune response

The paper identifies a novel dsRNA virus in Malassezia restricta, shows it alters gene expression and cell morphology, and induces TLR3-mediated inflammation in dendritic cells.

Inhibition of tumor growth by a novel engineered chimeric toxin that cleaves activated mutant and wild-type RAS

This paper develops a chimeric toxin that cleaves both mutant and wild-type RAS, reducing tumor burden in mouse models.

Stepwise autophosphorylation regulates biased agonism of the insulin receptor

This study shows that stepwise autophosphorylation of the insulin receptor is regulated by symmetric insulin binding, leading to biased agonism with metabolic effects.