Free fatty acid receptor 4 (FFAR4) regulates cardiac oxylipin balance to promote inflammation resolution in a model of heart failure preserved ejection fraction secondary to metabolic syndrome
N. Zhang, K. A. Murphy, B. Harsch, M. Zhang, D. J. Gyberg, B. M. Wagner, J. Mendelson, M. T. Patterson, D. A. Orchard, C. L. Healy, J. W. Williams, G. C. Shearer, T. O'Connell
This study shows that Ffar4 loss worsens cardiac inflammation and remodeling in male HFpEF-MetS mice by altering oxylipin balance.
bioRxiv · Apr 13, 2022 · PreprintPhysiology