Paradoxical activation of a type VI secretion system (T6SS) phospholipase effector by its cognate immunity protein
S. J. Jensen, Z. C. Ruhe, A. Williams, D. Q. Nhan, F. Garza-Sanchez, D. Low, C. S. Hayes
The paper identifies that disruption of the tli immunity gene in Enterobacter cloacae leads to hyper-permeability via unopposed Tle phospholipase activity, revealing distinct roles for Tli based on its subcellular localization.
bioRxiv · Mar 28, 2023Microbiology