A. Williams

Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis

This study identifies proteomic differences in neutrophils from MS patients compared to healthy donors, highlighting dysregulated granule proteins and MAVS signaling, and impaired T cell suppression.

Strong signatures of selection on genes underlying core reinforcement mechanisms in speciating desert tortoises

The paper identifies genes under positive selection in desert tortoises linked to reproductive isolation mechanisms and environmental adaptation.

Placental Nanoparticle-mediated IGF1 Gene Therapy Corrects Fetal Growth Restriction in a Guinea Pig Model

This paper demonstrates that placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model by improving fetal weight, blood glucose, and reducing cortisol levels.

The Hyaluronan Synthase isoforms direct distinct patterns of fibroblast activation linked to fibrosis progression versus resolution following renal ischaemia

This study compares HA and HAS enzyme expression in kidney development, health, disease, and recovery, identifying distinct roles of HAS1 and HAS2 in fibroblast activation linked to fibrosis progression versus resolution.

Far-red and sensitive sensor for monitoring real-time H2O2 dynamics with subcellular resolution and inmulti-parametric imaging applications.

This paper introduces a new fluorescent sensor, oROS-HT, for real-time H2O2 monitoring with subcellular resolution and multi-parametric imaging capabilities.

Designing Bt constructs for Brassicas, with minimal IP issues: A case study

The paper designs modified Bt Cry1BM and Cry1CM genes for Brassicas to reduce licensing costs and IP issues, showing high insecticidal efficacy in transgenic Arabidopsis.

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

DNA from non-viable bacteria biases diversity estimates in the corals Acropora loripes and Pocillopora acuta

The paper shows that DNA from non-viable bacteria can bias diversity estimates in corals, using PMA treatment to distinguish viable from non-viable DNA.

Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells

This study shows that deleting adhesion ligands CD54 and CD58 on allogeneic immune cells reduces NK cell rejection without impairing their anti-tumor activity.

Diet composition drives tissue-specific intensity of murine enteric infections

This study shows that diet composition affects tissue-specific susceptibility to enteric infections in mice, with fiber-rich diets increasing pathogen burden in some cases.

Protocol for primary human lung organoid-derived air-liquid interface in vitro model to study response to SARS-CoV-2

This paper presents a protocol for creating human lung organoid-derived air-liquid interface cultures to study SARS-CoV-2 infection and includes quality control and monitoring methods.

Microsecond dynamics control the HIV-1 envelope conformation

This study uses time-resolved scattering to observe microsecond dynamics in HIV-1 Env, revealing rapid transitions that conventional strategies may not address.

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia

This study examines the spatiotemporal immune response to SARS-CoV-2 in human broncho-alveolar epithelia, finding variant-specific kinetics and spatially organized gene expression patterns.

Paradoxical activation of a type VI secretion system (T6SS) phospholipase effector by its cognate immunity protein

The paper identifies that disruption of the tli immunity gene in Enterobacter cloacae leads to hyper-permeability via unopposed Tle phospholipase activity, revealing distinct roles for Tli based on its subcellular localization.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Computational Prediction of Binding Affinities of Human Angiotensin Converting Enzyme-2 with SARS-CoV-2 Spike Protein Variants: Omicron Variants and Potentially Deleterious Mutations

The paper predicts binding affinities of SARS-CoV-2 spike protein variants and mutations to ACE2 using a computational protocol, showing good agreement with experimental data.

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

The paper uses machine learning to analyze human-chimpanzee variants in HARs, finding 43% affect chromatin state and 14% affect neurodevelopmental enhancer activity, with species-specific activity predicted by transcription factor footprints.

Signal and Measurement Considerations for Human Translation of Diffuse in vivo Flow Cytometry

This study evaluates the feasibility of detecting fluorescent signals from circulating cells in human blood vessels using diffuse in vivo flow cytometry (DiFC) by analyzing instrument geometry, wavelength, and tissue properties.

The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

This study shows cathelicidin promotes Th17 responses and severe EAE by enhancing T cell differentiation and plasticity, and its absence protects mice from disease.

Endowing Universal CAR T-cell with Immune-Evasive Properties using TALEN-Gene Editing.

This paper develops a novel CAR T-cell scaffold with immune-evasive properties to enable universal allogeneic CAR T-cell therapy.

The retromer complex regulates C. elegans development and mammalian ciliogenesis

This study shows the retromer complex is essential for C. elegans development and mammalian ciliogenesis, with a role in CP110 removal from the mother centriole.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Acetylation regulates the oligomerization state and activity of RNase J, the major ribonuclease of Helicobacter pylori

This study identifies acetylation of RNase J in H. pylori as a regulatory mechanism that modulates its oligomerization state and enzymatic activity.

Divergent epigenetic profiles from two differentially impacted wild populationsof estuarine cordgrass (Sporobolus alterniflorus)

This study examines how two populations of estuarine cordgrass show opposite DNA methylation patterns under heat stress, suggesting epigenetic mechanisms may enable rapid adaptation to urban environmental challenges.

Single cell analysis of blood mononuclear cells stimulated through CD3 and CD28 shows collateral activation of B and NK cells and demise of monocytes

The paper uses single-cell RNA-seq and CITE-seq to analyze PBMC responses to T-cell and monocyte activators, showing differential activation patterns and transcriptional changes in various immune cell types.

The auxin transporter PIN1 and the cytokinin transporter AZG1 interact to regulate the root stress response

This study identifies AZG1 as a cytokinin transporter that interacts with PIN1, an auxin transporter, to regulate root system architecture in response to environmental stress.

Towards a general model for predicting minimal metal concentrations co-selecting for antibiotic resistance plasmids

The paper develops a mathematical model to predict minimal metal concentrations that co-select for antibiotic resistance plasmids, applying it to copper, zinc, mercury, lead, and silver.

Prolonged low-dose dioxin exposure impairs metabolic adaptability to high-fat diet feeding in female but not male mice

Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses

This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.