A mutation associated with Charcot-Marie-Tooth disease enhances the formation of stable dynamin 2 complexes in cells
P. N. Hedde, B. Barylko, C.-L. Chiu, J. P. Albanesi, D. M. Jameson, N. G. James
This study shows a CMT-causing DNM2 mutation, {Delta}DEE, fails to undergo auto-inhibition and forms cytoplasmic inclusions, similar to CNM mutants, challenging the current understanding of disease-specific mechanisms.
bioRxiv · Dec 13, 2021 · PreprintCell Biology