P. N. Hedde

This study shows a CMT-causing DNM2 mutation, {Delta}DEE, fails to undergo auto-inhibition and forms cytoplasmic inclusions, similar to CNM mutants, challenging the current understanding of disease-specific mechanisms.

This study uses fluorescence nanoimaging to show that Arc/Arg3.1 exists as monomers and dimers in the cytoplasm and is predominantly monomeric and more diffusive in the nucleus, moving freely between PML-NBs and nucleoplasm.

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

This paper introduces MOSAICA, a spatial transcriptomics technology that combines spectral and lifetime encoding with machine learning to enable highly multiplexed in situ biomarker profiling.

This paper introduces ultrafast phasor-based hyperspectral snapshot microscopy for biomedical imaging, achieving 10-100x faster imaging speeds and enabling metabolic imaging of live 3D mouse tissues.

The paper introduces a low-cost, portable imaging system for specific COVID-19 antibody testing using microarrays, achieving performance comparable to expensive commercial readers.