S. Malik

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

Glutamine addiction is targetable via altering splicing of nutrient sensors and epitranscriptome regulators

This study shows PRMT5 inhibition targets MNA neuroblastoma by altering splicing of nutrient sensors and epitranscriptome regulators, leading to growth inhibition and apoptosis.

Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy

Voluntary wheel running improves muscle function and reduces tubular aggregates in a mouse model of tubular aggregate myopathy.

Differential Carbonic Anhydrase Activities Control EBV-Induced B-Cell Transformation and Lytic Cycle Reactivation

This study shows that differential carbonic anhydrase activities regulate EBV-induced B-cell transformation and lytic cycle reactivation through transcriptional control by EBNA2 and BZLF1.

PD1 is transcriptionally regulated by LEF1 in mature T cells

This study shows LEF1, not TCF1, regulates PD1 transcription in mature T cells, with implications for cancer immunotherapy.

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

This study develops anti-seed PNAs targeting oncomiRs 10b and 21 for GBM therapy, showing improved tumor growth inhibition and survival in mice.

Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity

This study combines tipifarnib and alpelisib to target PI3K-mTOR and HRAS in HNSCC, showing synergy in mTOR inhibition and clinical potential for R/M HNSCC patients.

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney disease

This study uses single-cell RNA sequencing to identify disrupted cell-cell communication in a mouse model of WT1 kidney disease, highlighting non-immunological pathology and suggesting vascular-targeted therapies.

Regulation of Store-Operated Ca2+ Entry by IP3 Receptors Independent of Their Ability to Release Ca2+

The paper shows IP3Rs regulate neuronal SOCE through IP3 binding, independent of Ca2+ release, by enhancing STIM1-Orai1 association.

Computational exploration of bio-remediation solution for mixed plastic waste

The paper analyzes biodegradation patterns of plastics and identifies potential microbial genera for bioremediation of mixed plastic waste.

Effect of artificial light at night on sleep and metabolism in weaver birds

This study examines the effects of artificial light at night on sleep and metabolism in baya weavers, finding acute exposure causes more pronounced behavioral and physiological changes.

Characterization of clostridium botulinum neurotoxin serotype A (BoNT/A) and fibroblast growth factor receptor interactions using a novel receptor dimerization assay

This paper develops a receptor dimerization assay to study BoNT/A interactions with FGFRs, showing HC/A induces FGFR dimerization with potency varying by receptor subtype.

Heme Attenuates Endogenous Opioid Levels in Leukocytes of HIV positive individuals with Chronic Widespread Pain

This study shows that heme-induced ER stress in leukocytes of HIV-positive individuals with chronic widespread pain reduces β-endorphin levels, contributing to increased pain sensitivity.

Proteasomal Inhibition Triggers Viral Oncoprotein Degradation via Autophagy-Lysosomal Pathway

This study shows proteasomal inhibition causes degradation of EBNA3A and EBNA3C viral oncoproteins via autophagy-lysosomal pathway, while EBNA3B remains stable, suggesting potential therapeutic use of proteasome inhibitors for EBV-related B-cell lymphomas.

Wnt signalling drives context-dependent differentiation or proliferation in neuroblastoma

This study identifies Wnt target genes in neuroblastoma and shows Wnt signalling can drive differentiation in some cell lines and proliferation in others.