Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib
C. Lim, T. Dismuke, D. Malawsky, J. D. Ramsey, D. Hwang, V. L. Godfrey, A. V. Kabanov, T. R. Gershon, M. Sokolsky
This study improves CDK4/6 inhibitor therapy for medulloblastoma by combining nanoparticle delivery with scRNA-seq-guided identification of sapanisertib, enhancing survival in mice.
bioRxiv · Jun 9, 2021Cancer Biology