C. Lim

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

Tumor microenvironment immunomodulation by nanoformulated TLR 7/8 agonist and PI3k delta inhibitor enhances therapeutic benefits of radiotherapy

This study shows that combining nanoformulated TLR7/8 agonist and PI3K delta inhibitor with radiotherapy improves anti-tumor activity in TNBC by modulating the tumor microenvironment.

Smad4 Loss in the Mouse Intestinal Epithelium Alleviates the Pathological Fibrotic Response to Injury in the Colon

This study shows that Smad4 loss in the mouse intestinal epithelium reduces pathological fibrosis and improves mucosal repair after DSS-induced injury.

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria

This paper shows that Corynebacterium diphtheriae toxin activates NLRP1 inflammasome and pyroptosis in keratinocytes via ribotoxic stress response pathways.

High-Dose Paclitaxel and its Combination with CSF1R Inhibitor in Polymeric Micelles for Chemoimmunotherapy of Triple Negative Breast Cancer

This study evaluates high-dose paclitaxel and its combination with CSF1R inhibitor in polymeric micelles for chemoimmunotherapy of triple-negative breast cancer, showing improved therapeutic outcomes and immune response.

A 96-WELL VALVED MICROFLUIDIC DEVICE FOR TESTING OF LIVE INTACT TUMOR CUBOIDS

The paper introduces a 96-well microfluidic device for testing drug responses in live tumor cuboids, preserving the tumor microenvironment for personalized oncology applications.

PEG-Free Polyion Complex Nanocarriers for Brain Derived Neurotrophic Factor

This paper reformulates PEG-based polyion complex nanocarriers for BDNF with non-PEG polymers, maintaining self-assembly and receptor accessibility without compromising stability.

Targeting OLIG2 increases therapeutic responses in SHH medulloblastoma mouse models and patient-derived medulloblastoma organoids

This study shows that targeting OLIG2 with CT-179 reduces recurrence in SHH medulloblastoma models and improves survival when combined with radiotherapy.

Nanoformulated Remdesivir with Extremely Low Content of Poly(2-oxazoline) - Based Stabilizer for Aerosol Treatment of COVID-19

Bioequivalence Assessment of High-Capacity Polymeric Micelle Nanoformulation of Paclitaxel and Abraxane(R) in Rodent and Non-Human Primate Models Using a Stable Isotope Tracer Assay

Dystrophin regulates peripheral circadian SRF signalling

This study shows dystrophin loss disrupts the RhoA-actin-SRF pathway, leading to circadian dysregulation in muscle and peripheral tissues.

Drug-dependent morphological transitions in spherical and worm-like polymeric micelles define stability and pharmacological performance of micellar drugs

This study evaluates how the morphology of polymeric micelles affects their pharmacological performance, finding that spherical micelles are more effective for drug delivery when drugs are loosely associated.

Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib

This study improves CDK4/6 inhibitor therapy for medulloblastoma by combining nanoparticle delivery with scRNA-seq-guided identification of sapanisertib, enhancing survival in mice.

Rampant prophage movement among transient competitors drives rapid adaptation during infection

The paper shows prophage-mediated active lysogeny drives rapid, parallel adaptations in bacterial infections by disrupting global regulator genes, increasing cyclic-di-GMP and biofilm production.

Local protein synthesis of mtIF3 regulates mitochondrial translation for axonal development

This study shows BDNF induces local mtIF3 translation in axons, which supports mitochondrial translation and is necessary for axonal growth.

Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi

The paper identifies a novel bacterial guanine nucleotide exchange factor (GEF) in Orientia tsutsugamushi that activates Rac1 and alters cell morphology.

Histone acetylome-wide association study of tuberculosis

This study conducts a histone acetylome-wide association study (HAWAS) of tuberculosis, identifying differentially acetylated loci and their association with immune phenotypes.

A conserved acidic cluster motif in SERINC5 confers resistance to antagonism by HIV-1 Nef

This paper identifies an acidic cluster motif in SERINC5 that mediates resistance to HIV-1 Nef antagonism, showing its importance in Nef sensitivity without affecting intrinsic antiviral activity.

Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway

This paper shows bacteria enhance mammalian NAD metabolism by using a deamidated biosynthesis pathway, contributing to drug resistance and improving NAD-boosting efficiency.

Phosphoserine acidic cluster motifs in the cytoplasmic domains of transmembrane proteins bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes

The paper identifies that phosphoserine acidic cluster motifs in transmembrane proteins bind distinct basic regions on clathrin adaptor protein μ subunits, revealing potential for virus-specific inhibition.