Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor
T. Capraz, N. F. Kienzl, E. Laurent, J. W. Perthold, E. Foederl-Hoebenreich, C. Gruenwald-Gruber, D. Maresch, V. Monteil, J. Niederhoefer, G. Wirnsberger, A. Mirazimi, K. Zatloukal, L. Mach, J. M. Penninger, C. Oostenbrink, J. Stadlmann
This study engineers ACE2 glycosylation to enhance its binding to SARS-CoV-2 Spike protein, resulting in a more potent decoy receptor for COVID-19 treatment.
bioRxiv · Aug 31, 2021Biochemistry