Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development
M. D. Ryser, M. A. Greenwald, I. C. Sorribes, L. M. King, A. Hall, J. Geradts, D. L. Weaver, D. Mallo, S. Holloway, D. Monyak, G. Gumbert, S. Vaez-Ghaemi, E. Wu, K. A. Murgas, L. J. Grimm, , S. Hwang
This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.
bioRxiv · Oct 1, 2023 · PreprintCancer Biology