A. Hall

MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma

Unveiling Vaginal Fibrosis: A Novel Murine Model Using Bleomycin and Epithelial Disruption

This study develops a murine vaginal fibrosis model using bleomycin and epithelial disruption, showing fibrosis at 3 weeks with resolution by 6 weeks.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.

Integrated Fluorescence Microscopy (iFLM) for Cryo-FIB-milling and In-situ Cryo-ET

The paper develops an integrated fluorescence microscope module for cryo-FIB-SEM to enable efficient 3D correlative workflows for cryo-ET sample preparation.

Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma

This study shows glucose deprivation in lung adenocarcinoma causes de-differentiation and an aggressive phenotype through epigenetic changes and HIF1 activation.

Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

This study shows that phosphorylation by multiple kinases inhibits Cdc15 phase separation and prevents cytokinetic ring assembly in fission yeast.

Introgression of the Triticum timopheevii genome into wheat detected by chromosome-specific KASP markers

The paper develops chromosome-specific KASP markers to detect introgression of Triticum timopheevii genome into wheat, identifying extensive recombination with wheat genomes.

Exotic alleles contribute to heat tolerance in wheat under field conditions

This study identifies exotic alleles from Aegilops tauschii that enhance heat tolerance in wheat without reducing yield under favorable conditions.

Air pollution induces Staphylococcus aureus USA300 respiratory tract colonisation mediated by specific bacterial genetic responses dependent on the global virulence gene regulators Agr and Sae

This study shows that exposure to black carbon increases Staphylococcus aureus virulence and colonization by altering gene expression, independent of host factors.

Circadian and diel regulation of photosynthesis in the bryophyte Marchantia polymorpha

This study investigates circadian regulation of photosynthesis in the liverwort Marchantia polymorpha, finding that light-dark cycles synchronize photosynthetic rhythms, while chloroplast translation is necessary for clock control of light harvesting.

Circadian regulation of the transcriptome in a complex polyploid crop

This study investigates circadian regulation of homoeologous gene triads in hexaploid bread wheat, finding imbalanced rhythmic expression and conserved biological processes with Arabidopsis.

Synergistic Enzyme Mixtures to Realize Near-Complete Depolymerization in Biodegradable Polymer/Additive Blends

This study shows that synergistic enzyme mixtures can achieve near-complete depolymerization of polymer/additive blends by combining random chain scission and processive depolymerization.

Identifying genomic regions and candidate genes selected during the breeding of rice in Vietnam

The paper identifies genomic regions and candidate genes selected during rice breeding in Vietnam by analyzing allele frequency patterns and population differentiation across subpopulations.

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

Uncovering candidate genes involved in photosynthetic capacity using unexplored genetic variation in Spring Wheat

The paper identifies candidate genes for photosynthetic capacity in wheat by analyzing genetic variation and hyperspectral data from diverse wheat germplasm.

Embedded Enzyme Nanoclusters Depolymerize Polyesters via Chain-End Mediated Processive Degradation

This paper demonstrates that enzyme nanoclusters can depolymerize polyesters via chain-end mediated processive degradation, enabling scalable bioactive plastics for efficient sorting.

Minimal Barriers to Invasion During Human Colorectal Tumor Growth

The paper examines intra-tumoral heterogeneity in colorectal tumors and finds that early multiclonal invasion occurs with minimal barriers to invasion.

Unmasking the tissue microecology of ductal carcinoma in situ with deep learning

This paper develops a deep learning pipeline to detect and segment DCIS ducts, revealing that pure DCIS has more TILs but less co-localization with ducts compared to adjacent DCIS.

TGFβ in the obese liver mediates conversion of NK cells to a less cytotoxic ILC1-like phenotype

This study shows that TGFβ in obese livers converts NK cells to a less cytotoxic ILC1-like phenotype, which may protect against NAFLD but increase cancer risk.

Circadian diversity in Swedish Arabidopsis accessions is associated with naturally occurring genetic variation in COR28

The paper identifies a non-synonymous SNP in COR28 associated with circadian period and flowering time variation in Swedish Arabidopsis accessions.

A high-throughput delayed fluorescence method reveals underlying differences in the control of circadian rhythms in Triticum aestivum and Brassica napus

This study optimizes delayed fluorescence imaging for high-throughput circadian period measurement in wheat and oilseed rape, revealing species-specific differences in circadian robustness.

Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

The paper compares immune cell infiltration in primary and metastatic breast tumors, finding reduced immune cell abundance but increased M2-like macrophages in metastases.

FDA-ARGOS: A Public Quality-Controlled Genome Database Resource for Infectious Disease Sequencing Diagnostics and Regulatory Science Research

The paper introduces FDA-ARGOS, a quality-controlled genome database for infectious disease sequencing, and demonstrates its use in diagnostics and validation.

Elucidating the genetic basis of biomass accumulation and radiation use efficiency in spring wheat and its role in yield potential

This study identifies genetic markers associated with biomass and radiation use efficiency in spring wheat, showing their potential to improve yield through marker-assisted breeding.

Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis

The paper shows transition bias drives antibiotic resistance mutations in Mycobacterium tuberculosis, suggesting mutation supply, not selection, is the cause.

The electron transport chain sensitises Staphylococcus aureus and Enterococcus faecalis to the oxidative burst

The paper shows that loss of the electron transport chain in Staphylococcus aureus and Enterococcus faecalis SCVs increases resistance to the oxidative burst in human blood.

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration

The paper identifies GEFs regulating collective cell migration by screening human bronchial epithelial cells, showing RHOA GEFs influence intercellular communication and motility.