E. Wu

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

Rapid and Highly Efficient Morphogenic Gene-Mediated Hexaploid Wheat Transformation

This paper introduces two methods for morphogenic gene-mediated wheat transformation with high efficiency and reduced tissue culture time.

Impact of cannabis use on immune cell populations and the viral reservoir in people with HIV on suppressive antiretroviral therapy.

This study examines how cannabis use affects immune cell populations and the HIV reservoir in HIV-positive individuals on antiretroviral therapy, finding reduced T cell activation and potential reservoir size reduction in some subgroups.

Actin filaments accumulate in the nucleus during interphase and remain in the vicinity of condensing chromosomes during prophase to metaphase in zebrafish early embryos

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

Nanog organizes transcription bodies

The paper shows Nanog organizes transcription bodies by clustering with Sox19b and RNA polymerase II, requiring its DNA-binding domain and an intrinsically disordered region.

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

Comprehensive and Integrated Genomic Characterization of Human Immunome in Cancer

This study develops a network-based immunogenomics model to identify mutations affecting immune responses in cancer and suggests potential immunomodulatory drug candidates.

An efficient gene excision system in maize

This paper develops an efficient gene excision system in maize using inducible recombinases to improve transformation and regeneration of fertile plants.

Efficient Gene Targeting in Maize using Inducible CRISPR-Cas9 and Marker-Free Donor Template

This paper demonstrates efficient, marker-free gene targeting in maize using inducible CRISPR-Cas9 and a donor template, achieving high mutation rates and heritable results in the T0 generation.