Dynamics of Prion Proliferation Under CombinedTreatment of Pharmacological Chaperones andInterferons via a Mathematical Model
A. Ghosh, D. N. Garzon, Y. Castillo, M. Navas-Zuloaga, N. Culik, L. Darwin, A. Hardin, A. Yang, C. C. Garsow, K. Rios-Soto
This study develops a mathematical model to analyze how pharmacological chaperones and interferons affect prion proliferation, finding interferons are more potent at lower doses but combined therapy offers greater benefits.
bioRxiv · Jul 6, 2020 · PreprintCell Biology