A. Yang

Maternal Immunoglobulin A regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses

This study shows that maternal IgA suppresses Enterobacteriaceae colonization and prevents the development of intestinal microbiota-specific CD4+ T cells in neonates.

High refresh rate display for natural monocular viewing in AOSLO psychophysics experiments

This paper demonstrates a high refresh rate display integrated with an AOSLO to enable natural monocular viewing and precise psychophysics experiments with high spatial and temporal resolution.

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

Differential seasonal effects of ephemeral legumes in response to moisture-nitrogen coupling in the deserts of northwestern China

This study examines how moisture and nitrogen affect two desert legumes, showing growth and chlorophyll differences under varying treatments, with moisture-nitrogen coupling influencing physiological responses.

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

Not dasycladalean alga, but an Odyssey of the earliest Phanerozoic animal reef-builders

The paper reclassifies Protomelission? sp. as archaeocyath-like sponges, challenging previous interpretations and providing insights into early animal reef-building.

Vicious cycle of hemodynamic perturbation and endothelial injury in development and progression of pulmonary arterial hypertension

This study shows that hemodynamic perturbations and endothelial injury form a cycle driving pulmonary arterial hypertension, which can be reversed by unilateral lung banding.

De novo design of buttressed loops for sculpting protein functions

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics

This study uses multi-scaled transcriptomics to investigate immune-epithelial dynamics and tissue remodeling in chronic rhinosinusitis, identifying novel cellular interactions and trajectories associated with nasal polyps.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

Improved Ethanol Tolerance and Production in Pyruvate Dehydrogenase Mutant of Saccharomyces cerevisiae

This study creates a Pyruvate Dehydrogenase (PDH) deficient S. cerevisiae strain that shows improved ethanol production and tolerance.

Role of HAO2 in rats with chronic kidney disease by regulating fatty acid metabolic processes in renal tissue

This study identifies HAO2 as a regulator of fatty acid metabolism in CKD rat kidneys, showing its reduced expression and role in lipid accumulation and metabolic dysfunction.

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

An RFX transcription factor regulated ciliogenesis in the progenitors of choanoflagellates and animals

This study investigates the role of RFX transcription factors in ciliogenesis in choanoflagellates and animals, finding that the RFX/FoxJ1 module predates animal divergence and regulates ciliary gene expression.

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

A Cambrian soft-bodied conical animal illustrates the origins of lophophorate phyla

The paper describes a Cambrian fossil with features of multiple lophophorate phyla, suggesting an intermediate evolutionary position between Phoronida and Brachiopoda.

Exploration of BAY 11-7082 as a novel antibiotic

The paper identifies BAY 11-7082 as a molecule that stimulates biofilm formation in Pseudomonas aeruginosa and inhibits growth of MRSA and other pathogens, with analogues showing enhanced anti-Staphylococcal activity.

Germinal center activity and B cell maturation promote protective antibody responses against Plasmodium pre-erythrocytic infection

This study compares vaccine-induced antibody responses in two mouse strains, finding that BALB/cJ mice develop stronger protective antibodies against Plasmodium due to enhanced B cell maturation and germinal center activity.

Surveillance of in situ tumor arrays reveals early environmental control of cancer immunity

This study introduces STAMP, a method to monitor tumor-immune dynamics in vivo, showing immune phenotypes evolve over time and correlate with therapeutic response.

The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

METTL9 regulates N1-histidine methylation of zinc transporters to promote tumor growth

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

A cross-nearest neighbor/Monte Carlo algorithm for single molecule localization microscopy defines interactions between p53, Mdm2, and MEG3

The paper develops a cross-nearest neighbor/Monte Carlo algorithm to analyze interactions between p53, Mdm2, and MEG3 using single-molecule localization microscopy in U2OS cells.

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

Dynamics of Prion Proliferation Under CombinedTreatment of Pharmacological Chaperones andInterferons via a Mathematical Model

This study develops a mathematical model to analyze how pharmacological chaperones and interferons affect prion proliferation, finding interferons are more potent at lower doses but combined therapy offers greater benefits.

Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

Exploring Environmental Coverages of Species: A New Variable Selection Methodology for Rulesets from the Genetic Algorithm for Ruleset Prediction

This paper introduces a new variable selection method for species distribution models using GARP rulesets, showing it effectively identifies important environmental variables in simulations and real-world applications.

Comparison of antibody titres between intradermal and intramuscular rabies vaccination using inactivated vaccine in cattle in Bhutan.

This study compares antibody titres in cattle vaccinated intradermally versus intramuscularly with inactivated rabies vaccine, finding lower titres with the intradermal route despite reduced dose.

Ecological niche modeling the potential geographic distribution of four Culicoides species of veterinary significance in Florida

This paper uses ecological niche modeling to predict the geographic distribution of four Culicoides species in Florida and identifies key environmental predictors of their presence.