A. Ghosh

A large-scale crowd-sourced annotated acoustic dataset of Indian fauna

The paper creates a crowd-sourced acoustic dataset of Indian fauna to support biodiversity monitoring and deep learning applications in conservation.

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

Meta-omics reveals role of photosynthesis in Microbially Induced Carbonate Precipitation at a CO2-rich Geyser

The paper uses metagenomics and metaproteomics to study microbial communities at a CO2-rich geyser, finding photosynthesis and phosphorus limitation may influence MICP.

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

Role of VapBC4 toxin-antitoxin system of Sulfolobus acidocaldarius in heat stress adaptation

This paper characterizes the VapBC4 toxin-antitoxin system in Sulfolobus acidocaldarius, showing its role in heat stress adaptation through persister cell formation and biofilm regulation.

BUTYRATE AMELIORATES INFLAMMATION IN COLON BIOPSY SAMPLES OF IBD PATIENTS AND EXPERIMENTAL COLITIS IN MICE INVOLVING RNA BINDING PROTEIN, AUF1-IL-27 AXIS AND ACCELERATING B1a TO B10 POLARIZATION

This paper shows butyrate enhances B10 cell generation via the AUF1-IL-27 axis in IBD patients and mice, reducing inflammation.

Spatiotemporal dynamic models of Amblyomma americanum questing activity in the Central Great Plains

This study models the spatiotemporal dynamics of Amblyomma americanum questing activity using longitudinal sampling, randomization tests, and presence-absence modeling to improve understanding of tick-borne disease risk.

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

A novel micronemal protein, Scot1, is essential for apicoplast biogenesis and liver stage development in Plasmodium berghei

This paper identifies Scot1, a micronemal protein essential for late liver-stage development and apicoplast biogenesis in Plasmodium berghei, showing its potential as a target for malaria vaccines.

Sse1, Hsp110 chaperone of yeast, controls the cellular fate during Endoplasmic Reticulum-stress

This study shows that Sse1, a yeast Hsp110 chaperone, interacts with ER-UPR sensors and regulates ER protein homeostasis, ribosome reorganization, and cell division arrest during ER stress.

Heterotypic Seeding Generates Mixed Amyloid Polymorphs

This study shows that Aβ can form mixed polymorphs with different seeds, deviating from its typical parallel β structure, and highlights the complexity of Aβ aggregation in Alzheimer's disease.

Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune response

This paper identifies three neutralizing monoclonal antibodies against HAstV-VA1 and maps their epitopes, revealing four antigenic sites and immune pressure-driven mutations in a patient with encephalitis.

Age-related behavioral resilience in smartphone touchscreen interaction dynamics

The paper uses smartphone touchscreen interaction data to infer aging states and finds individuals exhibit fluctuating age-related behavioral resilience over time.

Translation initiation or elongation inhibition triggers contrasting effects on Caenorhabditis elegans survival during pathogen infection

This study shows that inhibiting translation initiation in C. elegans increases survival during P. aeruginosa infection, while inhibiting elongation decreases survival, due to distinct immune responses.

A genetic and physiological model of renal dysfunction in Lowe syndrome

This study uses a Drosophila nephrocyte model to show that OCRL loss causes endolysosomal defects and kidney dysfunction, which can be rescued by human OCRL but not by mutant variants.

Functional diversity in the Hsp60 of Sulfolobus acidocaldarius: mosaic of Group I and Group II chaperonin

This study investigates the functional mechanisms of Hsp60 in Sulfolobus acidocaldarius, revealing its role in protein folding and membrane protection under stress.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

Regions of Inflammation in mouse asthma correspond to regions of heme-free soluble guanylyl cyclase and can be tracked by marked expression of heme-oxygenase-1

The paper identifies inflammation regions in mouse asthma lungs that correlate with heme-free soluble guanylyl cyclase and HO1 expression, showing regional inflammation impacts lung function.

A novel vitamin C analog acts as a potent bio-enhancer to augment the activities of anti-tuberculosis drugs against Mycobacterium tuberculosis

The paper identifies a vitamin C analog, C11, that enhances anti-tuberculosis drug efficacy against M. tuberculosis by reducing mutant generation and increasing ROS production.

Control of Biofilm Formation by an Agrobacterium tumefaciens Pterin-Binding Periplasmic Protein Conserved Among Pathogenic Bacteria

This paper identifies a pterin-responsive regulatory mechanism in Agrobacterium tumefaciens that controls biofilm formation through interactions between PruR, DcpA, and pterins.

Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion

This study identifies novel SIRT3 activators that restore catalytic activity under NAD+ depletion, offering potential therapeutic applications for age-related diseases.

Enzalutamide Induces Cytotoxicity in Desmoplastic Small Round Cell Tumor Independent of the Androgen Receptor

The paper shows enzalutamide reduces DSRCT growth independently of AR, challenging the hypothesis that AR drives male predominance in this cancer.

Decoding the molecular interplay of endogenous CD20 and Rituximab with fast volumetric nanoscopy

The paper develops TDI-DNA-PAINT and LLS microscopy to study CD20-rituximab interactions in B cells, revealing oligomeric states and polarization effects.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

A novel glideosome-associated protein S14 coordinates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

α-Synuclein emulsifies TDP-43 prion-like domain - RNA liquid droplets to promote heterotypic amyloid fibrils

This study shows α-synuclein emulsifies TDP-43 prion-like domain-RNA droplets, promoting heterotypic amyloid fibril formation.

CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites

This study uses super-resolution microscopy to show CARs form nanodomains on T-cell membranes, accumulating at tumor sites, with transposon-engineered CARs showing higher density and faster anti-tumor activity.

Second messenger c-di-AMP regulates multiple antibiotic sensitivity pathways in Mycobacterium smegmatis by discrete mechanisms

This study shows that c-di-AMP modulates antibiotic sensitivity in M. smegmatis by interacting with protein effectors or mRNA 5-UTR regions, leading to differential drug resistance.

Peripheral vascular strand development in nodules is controlled by a bHLH/HLH heterodimer

This study identifies NVD1 and NVD2 heterodimers as critical regulators of peripheral vascular strand development in Medicago truncatula nodules, showing their role in maintaining proper vascular organization and auxin/cytokinin balance.

Intermediate antiparallel beta structure in amyloid plaques revealed by infrared spectroscopic imaging

The paper uses infrared spectroscopic imaging to show that amyloid plaques in Alzheimer's disease contain antiparallel beta-sheet structures, linking in vitro findings to in vivo pathology.